Metformin prescribed for longevity or metabolic health is a compounded or off label use of a medication traditionally indicated for the treatment of type 2 diabetes. While metformin is FDA approved for diabetes, its use for longevity is not FDA approved.
Who should not use metformin?
Do not use metformin if:
- You have severe kidney disease or significantly reduced kidney function
- You have metabolic acidosis, including diabetic ketoacidosis
- You have had a known allergic reaction or hypersensitivity to metformin or any of the ingredients in the formulation
- You have conditions associated with low oxygen levels such as severe heart failure, recent heart attack, or severe lung disease
- You consume excessive alcohol or have a history of alcohol abuse
How should I use metformin?
- Use metformin exactly as prescribed by your provider.
- Do not take more than the prescribed dose or take it more frequently than directed.
- Take metformin with meals to help reduce gastrointestinal side effects.
- Swallow tablets whole unless otherwise directed. Do not crush or chew extended release formulations.
- If you miss a dose, take it as soon as you remember unless it is close to your next dose. Do not double doses.
What should I tell my provider before using metformin?
Tell your provider about all medications you take, including prescription, over the counter medications, vitamins, and supplements.
Tell your provider if you:
- Have kidney or liver disease
- Have a history of heart disease or heart failure
- Drink alcohol regularly
- Are scheduled for imaging procedures with contrast dye
- Are pregnant, planning to become pregnant, or breastfeeding
- Have a history of vitamin B12 deficiency
- Have any condition that may increase your risk of dehydration
What are the most serious side effects that I or a caregiver should monitor for when taking metformin?
If you are experiencing a medical emergency, call 911 or seek immediate medical attention.
Stop using metformin and seek prompt medical care if you experience:
- Symptoms of lactic acidosis such as unusual fatigue, weakness, muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or slow or irregular heartbeat
- Signs of a severe allergic reaction such as rash, hives, swelling of the face, lips, tongue, or throat, or difficulty breathing
- Severe or persistent gastrointestinal symptoms such as vomiting or diarrhea leading to dehydration
- Signs of low blood sugar, especially if taken with other glucose lowering medications
What are the most common side effects of metformin?
Common side effects may include:
- Nausea
- Diarrhea
- Stomach upset
- Loss of appetite
- Metallic taste
- Vitamin B12 deficiency with long term use
This summary provides basic information about metformin but does not include all possible information or side effects. Your provider can answer questions about whether this medication is appropriate for you. Read the information provided with your prescription each time it is filled.